TIMTEC-BB SBB004230
Cycloleucine
CAS: 52-52-8
Molecular Formula: C6H11NO2
TIMTEC-BB SBB004230 - Names and Identifiers
TIMTEC-BB SBB004230 - Physico-chemical Properties
| Molecular Formula | C6H11NO2 |
| Molar Mass | 129.16 |
| Density | 1.1426 (rough estimate) |
| Melting Point | 320 °C (dec.) (lit.) |
| Boling Point | 239.22°C (rough estimate) |
| Flash Point | 108.7°C |
| Water Solubility | 5 g/100 mL |
| Vapor Presure | 0.00481mmHg at 25°C |
| Appearance | Solid |
| Color | White to beige |
| Merck | 14,2734 |
| BRN | 636626 |
| pKa | 2.38±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.4827 (estimate) |
| MDL | MFCD00001381 |
| In vitro study | Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m 6 A and the penultimate G m in B77 38S RNA subunits by greater than 90%. Cytostatic (10 µg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines. |
TIMTEC-BB SBB004230 - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GY2625000 |
| TSCA | Yes |
| HS Code | 29224999 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 290mg/kg |
TIMTEC-BB SBB004230 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Cycloleucine is a specific inhibitor of S-adenosylmethionine-mediated methylation. Cycloleucine is an antagonist of the glycine allosteric site of the NMDA receptor with a Ki value of 600 μM. Cycloleucine is also a competitive inhibitor of ATP:L-methionine-S-adenosyltransferase in vitro. Cycloleucine has anti-anxiety and cell inhibitory effects. |
| target | Ki: 600 μM (NMDA) |
| Animal Model: | Male rats bilaterally cannulated into the nucleus accumbens septi (NAS) |
| Dosage: | 1 µL of 0.5, 1.0, 2.0, 4 µg/µL |
| Administration: | Intracerebroventrical injection |
| Result: | Increased time spent in the open arms and extreme arrivals at all doses. Increased open arm entries at the dose of 4 μg. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 290 mg/kg; Oral-mouse LD50: 119 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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Product Name: Cycloleucine Visit Supplier Webpage Request for quotationCAS: 52-52-8
Tel: 18301782025
Email: 3008007409@qq.com
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Product Name: 1-Aminocyclopropane-1-carboxylic acid Request for quotation
CAS: 52-52-8
Tel: 13501999454
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Mobile: 13501999454
QQ: 544600049Send QQ message
CAS: 52-52-8
Tel: 13501999454
Email: yuki@yulibiotech.com
Mobile: 13501999454
QQ: 544600049
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